NCK1-DT

Across TCGA pan-cancer cohorts, NCK1-DT RNA differs between tumor and matched normal tissue in 16 of 18 cancer types tested, making tumor–normal expression one of NCK1-DT’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where NCK1-DT RNA is more highly expressed in tumor relative to normal tissue. In most cancer types NCK1-DT is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

KIRC, HNSC, and THCA are the cancer types where NCK1-DT tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in NCK1-DT RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	All	+0.898	<.001	12	view →
HNSC	Male	III,IV	+1.631	<.001	11	view →
THCA	All	IV	−0.917	<.001	11	view →
BLCA	All	All	+0.812	<.001	9	view →
LIHC	Male	All	+0.789	<.001	9	view →
STAD	Female	All	+1.081	<.001	7	view →
KIRP	All	All	+0.662	<.001	7	view →
LUSC	Female	All	+1.302	<.001	6	view →
UCEC	All	II,III,IV	+0.866	.013	6	view →
BRCA	Female	II,III,IV	+0.338	<.001	6	view →
CHOL	All	All	+1.592	<.001	3	view →
ESCA	All	II,III,IV	+1.105	.007	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 16 lineages.

NCK1-DT–KIRC

Open the KIRC breakdown →