NCEH1

Across TCGA patient cohorts, NCEH1 mutation is significantly associated with the RNA expression of many other genes, with 3,228 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NCEH1-associated genes across cancer lineages are AQP7P5, RNU6-841P, and SRRD. Each is linked with NCEH1 in more than 1 cancer types. Because this analysis shows association rather than direction, both NCEH1-to-partner and partner-to-NCEH1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, AQP7P5 grouped by NCEH1-low versus NCEH1-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NCEH1→partner) and Y-score (partner→NCEH1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	AQP7P5 →	+0.119	+3.395	<.001	.002	3	2
BLCA	RNU6-841P →	+0.243	+5.018	<.001	.004	3	2
UCEC	SRRD →	+0.434	+3.628	.001	.001	3	2
UCEC	LMF2 →	+0.496	+3.128	<.001	<.001	3	2
UCEC	MTHFD1 →	+0.669	+2.332	<.001	<.001	3	2
UCEC	SEC23A →	+0.647	+2.095	<.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,228 associations by consensus.

AQP7P5 by NCEH1 expression — SKCM

Explore this box plot interactively →