NCAM2

Across TCGA patient cohorts, NCAM2 mutation is significantly associated with the RNA expression of many other genes, with 7,120 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NCAM2-associated genes across cancer lineages are UAP1L1, HMBS, and TRMU. Each is linked with NCAM2 in more than 4 cancer types. Because this analysis shows association rather than direction, both NCAM2-to-partner and partner-to-NCAM2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, UAP1L1 grouped by NCAM2-low versus NCAM2-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NCAM2→partner) and Y-score (partner→NCAM2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	UAP1L1 →	+0.783	+2.700	<.001	.005	3	5
STAD	HMBS →	+0.468	+3.087	.003	<.001	3	5
STAD	TRMU →	+0.456	+3.203	<.001	.009	3	5
STAD	PMPCA →	+0.443	+2.415	.001	.003	3	5
UCEC	AKR1A1 →	+0.402	+1.459	<.001	<.001	3	5
COAD	FAXDC2 →	-0.689	-2.793	<.001	.002	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,120 associations by consensus.

UAP1L1 by NCAM2 expression — STAD

Explore this box plot interactively →