NCALD

Across TCGA patient cohorts, NCALD mutation is significantly associated with the total protein of many other genes, with 38 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NCALD-associated genes across cancer lineages are 14-3-3_beta, EGFR_pY1068, and A-Raf_pS299. Each is linked with NCALD in more than 1 cancer types. Because this analysis shows association rather than direction, both NCALD-to-partner and partner-to-NCALD results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 14-3-3_beta grouped by NCALD-low versus NCALD-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NCALD→partner) and Y-score (partner→NCALD) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	14-3-3_beta →	-0.122	-3.295	.004	.009	3	1
UCEC	EGFR_pY1068 →	-0.365	-2.459	<.001	.018	3	1
UCEC	A-Raf_pS299 →	-0.166	-2.321	.001	.034	3	1
UCEC	ERK2 →	+0.261	+2.222	.001	.011	3	1
UCEC	FoxM1 →	+0.248	+2.222	.024	.011	3	1
UCEC	ACC_pS79 →	+0.400	+2.222	.006	.011	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 38 associations by consensus.

14-3-3_beta by NCALD expression — UCEC

Explore this box plot interactively →