NCALD

Across TCGA pan-cancer cohorts, NCALD RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of NCALD’s most consistent transcriptional readouts.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where NCALD RNA is repressed in tumor relative to normal tissue. In most cancer types NCALD is over-expressed in tumor, although a few such as BLCA and LUAD show the opposite, repressed pattern.

BLCA, LUAD, and LUSC are the cancer types where NCALD tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in NCALD RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
BLCA	Male	IV	−3.307	<.001	9	view →
LUAD	All	III,IV	−1.115	<.001	9	view →
LUSC	All	III,IV	−1.961	<.001	8	view →
BRCA	All	III,IV	−2.076	<.001	6	view →
KIRC	All	All	+0.291	.006	6	view →
KICH	All	All	+1.193	.003	4	view →
KIRP	Female	II,III,IV	−0.990	.002	3	view →
THCA	Female	All	−0.372	.001	3	view →
UCEC	All	All	+0.575	.047	2	view →
PRAD	All	All	+0.430	.032	2	view →
CHOL	All	All	+0.794	.036	1	view →
STAD	All	All	−0.614	.048	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

NCALD–BLCA

Open the BLCA breakdown →