NBPF11

Across TCGA patient cohorts, NBPF11 mutation is significantly associated with the total protein of many other genes, with 30 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NBPF11-associated genes across cancer lineages are eIF4E, JNK_pT183_Y185, and JNK2. Each is linked with NBPF11 in more than 1 cancer types. Because this analysis shows association rather than direction, both NBPF11-to-partner and partner-to-NBPF11 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by NBPF11-low versus NBPF11-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NBPF11→partner) and Y-score (partner→NBPF11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.149	+2.598	.022	.005	3	2
UCEC	JNK_pT183_Y185 →	-0.157	-1.188	.002	.028	3	2
UCEC	JNK2 →	+0.244	+2.196	<.001	.001	3	2
UCEC	Notch1 →	+0.140	+2.424	.001	.001	3	2
UCEC	Rad50 →	-0.240	-1.906	.001	.015	3	2
UCEC	ASNS →	+0.352	+1.362	.001	.034	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 30 associations by consensus.

eIF4E by NBPF11 expression — UCEC

Explore this box plot interactively →