NBEAP1

Across TCGA pan-cancer cohorts, NBEAP1 RNA differs between tumor and matched normal tissue in 9 of 18 cancer types tested, making tumor–normal expression one of NBEAP1’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where NBEAP1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types NBEAP1 is over-expressed in tumor, although a few such as THCA and BRCA show the opposite, repressed pattern.

HNSC, THCA, and LUSC are the cancer types where NBEAP1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in NBEAP1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	II,III,IV	+0.251	<.001	10	view →
THCA	Male	III,IV	−0.220	<.001	10	view →
LUSC	Male	All	+0.536	<.001	6	view →
BRCA	All	All	−0.162	<.001	6	view →
PRAD	All	All	+1.004	.001	2	view →
UCEC	All	All	−0.125	.015	2	view →
READ	Female	All	−0.084	.017	2	view →
LIHC	Female	All	+0.064	.042	2	view →
KIRC	Male	All	−0.024	.047	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 9 strongest of 9 lineages.

NBEAP1–HNSC

Open the HNSC breakdown →