NBEAL2

Across TCGA cell cohorts, NBEAL2 mutation is significantly associated with the RNA expression of many other genes, with 509 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible NBEAL2-associated genes across cancer lineages are C12orf57, RNF225, and SERAC1. Each is linked with NBEAL2 in more than 1 cancer types. Because this analysis shows association rather than direction, both NBEAL2-to-partner and partner-to-NBEAL2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C12orf57 grouped by NBEAL2-low versus NBEAL2-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NBEAL2→partner) and Y-score (partner→NBEAL2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	C12orf57 →	+0.857	+2.130	<.001	<.001	3	2
BLOOD_Lymphoma	RNF225 →	+0.095	+3.459	<.001	.009	3	2
BLOOD_Leukemia	SERAC1 →	+0.557	+2.412	.003	.009	3	2
BLOOD_Leukemia	TREML1 →	+0.397	+2.446	.007	.004	3	2
BLOOD_Leukemia	TENT5C →	+1.134	+2.145	.009	.006	3	2
OVARY	OR14K1 →	+0.180	+2.906	<.001	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 509 associations by consensus.

C12orf57 by NBEAL2 expression — LARGE_INTESTINE

Explore this box plot interactively →