NBEA

Across TCGA patient cohorts, NBEA mutation is significantly associated with the total protein of many other genes, with 100 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NBEA-associated genes across cancer lineages are FOXO3a_pS318_S321, mTOR_pS2448, and ATM. Each is linked with NBEA in more than 4 cancer types. Because this analysis shows association rather than direction, both NBEA-to-partner and partner-to-NBEA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FOXO3a_pS318_S321 grouped by NBEA-low versus NBEA-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NBEA→partner) and Y-score (partner→NBEA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	FOXO3a_pS318_S321 →	-0.162	-2.481	.012	.001	3	5
COAD	mTOR_pS2448 →	-0.202	-2.205	<.001	.008	3	5
COAD	ATM →	-0.499	-2.222	<.001	.008	3	5
COAD	Caspase-7-cleavedD198 →	+0.881	+2.717	<.001	.002	3	5
STAD	eIF4E →	+0.262	+3.700	<.001	.001	3	4
COAD	FASN →	+0.438	+2.467	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 100 associations by consensus.

FOXO3a_pS318_S321 by NBEA expression — STAD

Explore this box plot interactively →