NBEA

Across TCGA cell cohorts, NBEA mutation is significantly associated with the RNA expression of many other genes, with 3,029 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible NBEA-associated genes across cancer lineages are PSIP1, CCDC171, and HSD17B6. Each is linked with NBEA in more than 3 cancer types. Because this analysis shows association rather than direction, both NBEA-to-partner and partner-to-NBEA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PSIP1 grouped by NBEA-low versus NBEA-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NBEA→partner) and Y-score (partner→NBEA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	PSIP1 →	+0.758	+3.513	.001	<.001	3	3
BLOOD_Lymphoma	CCDC171 →	+0.883	+2.516	<.001	.003	3	3
BLOOD_Lymphoma	HSD17B6 →	+0.887	+3.574	<.001	<.001	3	3
SKIN	IL31 →	+0.009	+2.169	<.001	.003	3	3
LARGE_INTESTINE	EIF3L →	+0.581	+1.891	<.001	<.001	3	3
LARGE_INTESTINE	GUCA1B →	+0.635	+2.115	.005	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,029 associations by consensus.

PSIP1 by NBEA expression — BLOOD_Lymphoma

Explore this box plot interactively →