NAXE

Across TCGA patient cohorts, NAXE mutation is significantly associated with the RNA expression of many other genes, with 61 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NAXE-associated genes across cancer lineages are RNU6-1205P, MIR30B, and TBC1D26-AS1. Each is linked with NAXE in more than 1 cancer types. Because this analysis shows association rather than direction, both NAXE-to-partner and partner-to-NAXE results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-1205P grouped by NAXE-low versus NAXE-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NAXE→partner) and Y-score (partner→NAXE) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	RNU6-1205P →	+0.516	+4.446	.001	.006	3	1
COAD	MIR30B →	+0.404	+5.122	<.001	.004	3	1
COAD	TBC1D26-AS1 →	+0.203	+4.209	<.001	.009	3	1
COAD	KCNQ1DN →	+0.089	+4.717	<.001	.003	3	1
COAD	RNU6-709P →	+0.742	+6.142	<.001	<.001	3	1
COAD	RN7SL131P →	+0.136	+4.693	.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 61 associations by consensus.

RNU6-1205P by NAXE expression — COAD

Explore this box plot interactively →