NAXE

Across TCGA pan-cancer cohorts, NAXE RNA is linked to patient survival in 28 of 34 cancer types, making it the most broadly survival-associated NAXE data layer compared with 3 for mutation status and 4 for mass-spec protein.

The strongest signal is observed in uveal melanoma (UVM), where higher NAXE RNA is associated with worse overall survival. In most high-consensus cancer types, elevated NAXE expression acts as an unfavorable survival marker, although some lineages such as LUSC and BRCA show a favorable association.

UVM, ACC, and KIRP are the cancer types where NAXE RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	OS	Median	All	0.443	0.744	<.001	108	view →
ACC	DFS	Median	All	0.232	0.666	<.001	95	view →
KIRP	DFS	Tertile	All	0.825	0.960	<.001	86	view →
KICH	OS	Tertile	II,III,IV	0.530	0.953	.001	67	view →
SKCM	OS	Median	All	0.278	0.393	<.001	61	view →
LAML	DFS	Median	All	0.323	0.591	<.001	54	view →
LGG	OS	Median	All	0.727	0.895	<.001	49	view →
UCEC	DFS	Tertile	All	0.572	0.738	<.001	42	view →
LIHC	OS	Median	All	0.610	0.765	<.001	38	view →
ESCA	DFS	Median	III,IV	0.293	0.572	<.001	36	view →
CESC	DFS	Median	All	0.667	0.809	.002	30	view →
LUAD	DFS	Median	II,III,IV	0.317	0.546	.004	28	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 28 lineages.

NAXE–UVM (OS)

Open the UVM breakdown →