NAV3

Across TCGA cell cohorts, NAV3 mutation is significantly associated with the RNA expression of many other genes, with 693 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible NAV3-associated genes across cancer lineages are RCHY1, AOC2, and MTDH. Each is linked with NAV3 in more than 3 cancer types. Because this analysis shows association rather than direction, both NAV3-to-partner and partner-to-NAV3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RCHY1 grouped by NAV3-low versus NAV3-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NAV3→partner) and Y-score (partner→NAV3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	RCHY1 →	+0.532	+3.087	<.001	<.001	3	4
LARGE_INTESTINE	AOC2 →	+0.420	+2.459	.007	.006	2	4
LARGE_INTESTINE	MTDH →	+0.469	+2.034	.007	.005	3	3
LARGE_INTESTINE	GLOD4 →	+0.539	+2.000	<.001	.009	3	3
OVARY	WFDC13 →	+0.061	+3.104	<.001	.002	3	3
LIVER	CLNK →	+0.012	+3.977	<.001	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 693 associations by consensus.

RCHY1 by NAV3 expression — LUNG_SCLC

Explore this box plot interactively →