NAV2-IT1

Across TCGA pan-cancer cohorts, NAV2-IT1 RNA is linked to patient survival in 13 of 34 cancer types, making it the most broadly survival-associated NAV2-IT1 data layer.

The strongest signal is observed in cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC), where higher NAV2-IT1 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated NAV2-IT1 expression acts as an unfavorable survival marker, although some lineages such as ACC and GBM show a favorable association.

CESC, READ, and UCEC are the cancer types where NAV2-IT1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CESC	OS	Tertile	IV	0.091	0.593	<.001	36	view →
READ	DFS	Tertile	II,III,IV	0.182	0.800	.011	36	view →
UCEC	OS	Tertile	All	0.305	0.708	.003	36	view →
STAD	DFS	Tertile	IV	0.083	0.379	.001	18	view →
BLCA	DFS	Tertile	All	0.360	0.610	.018	18	view →
MESO	OS	Tertile	IV	0.036	0.602	<.001	18	view →
ESCA	DFS	Tertile	All	0.420	0.795	.038	18	view →
LUAD	DFS	Quartile	IV	0.283	0.671	.019	12	view →
ACC	DFS	Tertile	All	0.912	0.543	.026	12	view →
COAD	OS	Tertile	III,IV	0.161	0.780	.018	9	view →
LIHC	OS	Quartile	All	0.612	0.714	.017	9	view →
HNSC	OS	Tertile	II,III,IV	0.160	0.369	.044	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 13 lineages.

NAV2-IT1–CESC (OS)

Open the CESC breakdown →