NAV2-IT1

Across TCGA pan-cancer cohorts, NAV2-IT1 RNA differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of NAV2-IT1’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where NAV2-IT1 RNA is repressed in tumor relative to normal tissue. In most cancer types NAV2-IT1 is over-expressed in tumor, although a few such as THCA and LUSC show the opposite, repressed pattern.

THCA, LUSC, and BRCA are the cancer types where NAV2-IT1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in NAV2-IT1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	All	All	−0.219	<.001	8	view →
LUSC	All	All	−0.053	.017	2	view →
BRCA	All	III,IV	−0.048	.016	2	view →
CHOL	All	All	−0.087	.030	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

NAV2-IT1–THCA

Open the THCA breakdown →