NAV2-AS4

Across TCGA pan-cancer cohorts, NAV2-AS4 RNA differs between tumor and matched normal tissue in 8 of 18 cancer types tested, making tumor–normal expression one of NAV2-AS4’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where NAV2-AS4 RNA is repressed in tumor relative to normal tissue. In most cancer types NAV2-AS4 is over-expressed in tumor, although a few such as THCA and KIRC show the opposite, repressed pattern.

THCA, KIRC, and KIRP are the cancer types where NAV2-AS4 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in NAV2-AS4 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Male	III,IV	−0.994	<.001	10	view →
KIRC	Male	III,IV	−0.107	<.001	10	view →
KIRP	Male	All	−0.101	<.001	8	view →
KICH	All	All	−0.124	<.001	7	view →
LUSC	Male	All	−0.046	<.001	7	view →
PRAD	All	All	−0.211	.012	2	view →
CHOL	All	All	−0.202	.020	2	view →
CHOL	All	II,III,IV	+0.084	.003	2	view →
STAD	All	All	−0.021	.015	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 9 strongest of 8 lineages.

NAV2-AS4–THCA

Open the THCA breakdown →