NAV2-AS2

Across TCGA pan-cancer cohorts, NAV2-AS2 RNA differs between tumor and matched normal tissue in 8 of 18 cancer types tested, making tumor–normal expression one of NAV2-AS2’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where NAV2-AS2 RNA is repressed in tumor relative to normal tissue. In most cancer types NAV2-AS2 is over-expressed in tumor, although a few such as KIRC and KIRP show the opposite, repressed pattern.

KIRC, KIRP, and LUAD are the cancer types where NAV2-AS2 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in NAV2-AS2 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	II,III,IV	−0.142	<.001	10	view →
KIRP	Male	All	−0.234	<.001	9	view →
LUAD	Female	III,IV	−1.962	<.001	7	view →
LUSC	Female	II,III,IV	−1.279	<.001	6	view →
KICH	All	All	−0.170	.002	5	view →
UCEC	All	All	−1.179	<.001	2	view →
BLCA	All	All	+0.108	.032	2	view →
LIHC	Male	III,IV	+0.098	.035	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 8 strongest of 8 lineages.

NAV2-AS2–KIRC

Open the KIRC breakdown →