Across TCGA pan-cancer cohorts, NAT8L mass-spec protein is linked to patient survival in 2 of 34 cancer types, making it a survival-associated NAT8L data layer compared with 24 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in glioblastoma multiforme (GBM), where higher NAT8L mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated NAT8L expression acts as an unfavorable survival marker.

GBM and CCRCC are the cancer types where NAT8L mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
GBM	OS	Tertile	All	0.246	0.643	.004	6	view →
CCRCC	DFS	Median	II,III,IV	0.149	0.752	.024	2	view →

Pink = unfavorable, green = favorable. Showing the 2 strongest of 2 lineages.

Exploration

Same gene, other analysis: NAT8L tumor-vs-normal RNA expression · all NAT8L data types