Across TCGA patient cohorts, NAT8L mutation is significantly associated with the RNA expression of many other genes, with 177 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NAT8L-associated genes across cancer lineages are RPS29P32, RNU7-29P, and RNU6-927P. Each is linked with NAT8L in more than 1 cancer types. Because this analysis shows association rather than direction, both NAT8L-to-partner and partner-to-NAT8L results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NAT8L→partner) and Y-score (partner→NAT8L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RPS29P32 →	+0.954	+3.599	<.001	<.001	3	2
BRCA	RNU7-29P →	+1.312	+8.055	<.001	.007	3	2
CESC	RNU6-927P →	+0.431	+5.103	<.001	.008	3	2
CESC	CYCSP29 →	+0.228	+5.103	<.001	.008	3	2
UCEC	MRE11P1 →	+0.066	+2.595	.004	.005	3	2
UCEC	C9orf43 →	+0.500	+3.234	.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 177 associations by consensus.

Exploration

NAT8L survival (RNA) · tumor vs normal (RNA) · all NAT8L data types