NAT1

Across TCGA cell cohorts, NAT1 mutation is significantly associated with the RNA expression of many other genes, with 2 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible NAT1-associated genes across cancer lineages are FIGLA and MBD3L4. Each is linked with NAT1 in more than 1 cancer types. Because this analysis shows association rather than direction, both NAT1-to-partner and partner-to-NAT1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FIGLA grouped by NAT1-low versus NAT1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NAT1→partner) and Y-score (partner→NAT1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	FIGLA →	+0.072	+5.415	<.001	.004	3	1
CNS	MBD3L4 →	+0.019	+5.321	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 2 strongest of 2 associations by consensus.

FIGLA by NAT1 expression — LARGE_INTESTINE

Explore this box plot interactively →