NASP

Across TCGA pan-cancer cohorts, NASP mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated NASP data layer compared with 22 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher NASP mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated NASP expression acts as an unfavorable survival marker, although some lineages such as LUAD and CCRCC show a favorable association.

LUAD, HNSC, and CCRCC are the cancer types where NASP mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	DFS	Tertile	III,IV	0.977	0.312	<.001	33	view →
HNSC	DFS	Tertile	All	0.331	0.852	.014	19	view →
CCRCC	DFS	Tertile	IV	0.887	0.260	.024	6	view →
PDAC	OS	Median	III,IV	0.370	0.813	.009	4	view →
LSCC	DFS	Tertile	II,III,IV	0.875	0.626	.045	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

NASP–LUAD (DFS)

Open the LUAD breakdown →