NASP

Across TCGA pan-cancer cohorts, NASP RNA differs between tumor and matched normal tissue in 16 of 18 cancer types tested, making tumor–normal expression one of NASP’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where NASP RNA is more highly expressed in tumor relative to normal tissue. In most cancer types NASP is over-expressed in tumor, although a few such as KICH and PRAD show the opposite, repressed pattern.

HNSC, KIRC, and LIHC are the cancer types where NASP tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in NASP RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	All	+1.004	<.001	11	view →
KIRC	Female	All	+0.646	<.001	11	view →
LIHC	Female	II,III,IV	+1.315	<.001	9	view →
STAD	Male	II,III,IV	+1.312	<.001	9	view →
LUAD	Male	All	+0.616	<.001	9	view →
LUSC	Female	All	+1.297	<.001	8	view →
BLCA	All	All	+0.911	<.001	8	view →
COAD	All	II,III,IV	+0.580	<.001	8	view →
UCEC	All	All	+0.586	.001	6	view →
CHOL	Male	All	+2.139	<.001	5	view →
KICH	Female	All	−0.866	<.001	5	view →
BRCA	All	II,III,IV	+0.217	.013	4	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 16 lineages.

NASP–HNSC

Open the HNSC breakdown →