NASP

Across TCGA patient cohorts, NASP mutation is significantly associated with the total protein of many other genes, with 29 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NASP-associated genes across cancer lineages are INPP4B, Notch1, and p27_pT198. Each is linked with NASP in more than 2 cancer types. Because this analysis shows association rather than direction, both NASP-to-partner and partner-to-NASP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, INPP4B grouped by NASP-low versus NASP-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NASP→partner) and Y-score (partner→NASP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	INPP4B →	-0.311	-2.807	.010	.003	3	2
UCEC	Notch1 →	+0.134	+2.183	.011	.033	3	2
UCEC	p27_pT198 →	+0.083	+1.415	.039	.046	3	2
UCEC	EGFR_pY1068 →	-0.232	-2.115	.013	.017	3	1
UCEC	eIF4G →	+0.287	+3.321	.013	.009	3	1
UCEC	A-Raf_pS299 →	-0.104	-2.459	.020	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 29 associations by consensus.

INPP4B by NASP expression — UCEC

Explore this box plot interactively →