NASP

Across TCGA cell cohorts, NASP mutation is significantly associated with the RNA expression of many other genes, with 5 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible NASP-associated genes across cancer lineages are DBX2, KLF18, and C5orf52. Each is linked with NASP in more than 1 cancer types. Because this analysis shows association rather than direction, both NASP-to-partner and partner-to-NASP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DBX2 grouped by NASP-low versus NASP-high in PANCREAS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NASP→partner) and Y-score (partner→NASP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	DBX2 →	+0.006	+5.000	<.001	.006	3	1
LARGE_INTESTINE	KLF18 →	+0.007	+3.345	<.001	.007	3	1
BLOOD_Leukemia	C5orf52 →	+0.036	+6.569	<.001	<.001	3	1
BLOOD_Leukemia	IQCF5 →	+0.121	+5.201	<.001	.006	3	1
LARGE_INTESTINE	NAT8 →	+0.598	+3.443	.003	.009	2	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

DBX2 by NASP expression — PANCREAS

Explore this box plot interactively →