NAPSA

Across TCGA cell cohorts, NAPSA mutation is significantly associated with the RNA expression of many other genes, with 25 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible NAPSA-associated genes across cancer lineages are SYT16, BANK1, and CYBB. Each is linked with NAPSA in more than 1 cancer types. Because this analysis shows association rather than direction, both NAPSA-to-partner and partner-to-NAPSA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SYT16 grouped by NAPSA-low versus NAPSA-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NAPSA→partner) and Y-score (partner→NAPSA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	SYT16 →	+0.243	+3.541	.009	.001	3	1
BLOOD_Lymphoma	BANK1 →	+2.720	+3.243	<.001	.006	3	1
BLOOD_Lymphoma	CYBB →	+2.846	+3.243	<.001	.006	3	1
BLOOD_Lymphoma	MT1B →	+0.385	+3.282	.002	<.001	3	1
BLOOD_Lymphoma	LRRC25 →	+1.071	+3.466	<.001	.004	3	1
BLOOD_Lymphoma	MPEG1 →	+2.803	+3.243	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 25 associations by consensus.

SYT16 by NAPSA expression — BLOOD_Lymphoma

Explore this box plot interactively →