NAPB

Across TCGA cell cohorts, NAPB mutation is significantly associated with the RNA expression of many other genes, with 6 significant associations in total. CNS shows the largest number of these associations.

The most reproducible NAPB-associated genes across cancer lineages are LHCGR, OR10W1, and CD300H. Each is linked with NAPB in more than 1 cancer types. Because this analysis shows association rather than direction, both NAPB-to-partner and partner-to-NAPB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LHCGR grouped by NAPB-low versus NAPB-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NAPB→partner) and Y-score (partner→NAPB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	LHCGR →	+0.050	+4.467	<.001	.004	3	1
LARGE_INTESTINE	OR10W1 →	+0.024	+5.562	<.001	<.001	3	1
LARGE_INTESTINE	CD300H →	+0.033	+4.415	<.001	.007	3	1
CNS	TRIM60 →	+0.006	+6.357	<.001	<.001	3	1
CNS	C10orf71 →	+0.016	+4.981	<.001	.008	3	1
CNS	FGF3 →	+0.053	+4.981	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

LHCGR by NAPB expression — LARGE_INTESTINE

Explore this box plot interactively →