NAPA-AS1

Across TCGA pan-cancer cohorts, NAPA-AS1 RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated NAPA-AS1 data layer.

The strongest signal is observed in kidney chromophobe (KICH), where higher NAPA-AS1 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated NAPA-AS1 expression acts as an unfavorable survival marker, although some lineages such as BRCA and HNSC show a favorable association.

KICH, COAD, and BRCA are the cancer types where NAPA-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KICH	DFS	Tertile	III,IV	0.257	1.000	.001	69	view →
COAD	DFS	Tertile	II,III,IV	0.299	0.806	<.001	62	view →
BRCA	OS	Median	II,III,IV	0.698	0.482	<.001	47	view →
ACC	DFS	Quartile	All	0.421	0.816	.002	34	view →
PAAD	DFS	Quartile	II,III,IV	0.303	0.540	.001	33	view →
HNSC	OS	Quartile	IV	0.442	0.240	.005	21	view →
BLCA	OS	Median	IV	0.216	0.619	.001	19	view →
KIRC	OS	Tertile	All	0.746	0.531	<.001	19	view →
SKCM	OS	Tertile	III,IV	0.554	0.257	.001	13	view →
ESCA	OS	Quartile	II,III,IV	0.690	0.353	.012	13	view →
LUSC	DFS	Median	All	0.705	0.609	.005	13	view →
THYM	DFS	Median	All	0.967	0.754	.007	10	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

NAPA-AS1–KICH (DFS)

Open the KICH breakdown →