NAPA-AS1

Across TCGA pan-cancer cohorts, NAPA-AS1 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of NAPA-AS1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where NAPA-AS1 RNA is repressed in tumor relative to normal tissue. In most cancer types NAPA-AS1 is over-expressed in tumor, although a few such as KICH and KIRP show the opposite, repressed pattern.

KICH, KIRP, and LIHC are the cancer types where NAPA-AS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in NAPA-AS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	Female	All	−1.305	<.001	10	view →
KIRP	Male	III,IV	−0.831	<.001	9	view →
LIHC	All	II,III,IV	+0.618	<.001	9	view →
LUAD	Male	All	+0.432	<.001	6	view →
LUSC	All	All	+0.333	<.001	6	view →
THCA	All	All	−0.245	<.001	5	view →
BRCA	Female	II,III,IV	−0.172	.004	4	view →
CHOL	All	All	+0.463	.006	2	view →
BLCA	Male	All	−0.419	.025	2	view →
PRAD	All	All	+0.224	.016	2	view →
KIRC	All	III,IV	+0.225	.043	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

NAPA-AS1–KICH

Open the KICH breakdown →