NANOGP8

Across TCGA pan-cancer cohorts, NANOGP8 RNA differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of NANOGP8’s most consistent transcriptional readouts.

The strongest signal is observed in lung adenocarcinoma (LUAD), where NANOGP8 RNA is repressed in tumor relative to normal tissue. In most cancer types NANOGP8 is over-expressed in tumor, although a few such as LUAD and UCEC show the opposite, repressed pattern.

LUAD, UCEC, and KIRP are the cancer types where NANOGP8 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in NANOGP8 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUAD	Female	II,III,IV	−0.100	<.001	4	view →
UCEC	All	III,IV	−0.097	.047	2	view →
KIRP	All	All	−0.047	.005	2	view →
CHOL	All	All	+0.142	.032	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

NANOGP8–LUAD

Open the LUAD breakdown →