NANOG

Across TCGA patient cohorts, NANOG protein abundance is significantly associated with the RNA expression of many other genes, with 7,311 significant associations in total. PDAC shows the largest number of these associations.

The most reproducible NANOG-associated genes across cancer lineages are GLS2, KISS1R, and LONRF2. Each is linked with NANOG in more than 3 cancer types. Because this analysis shows association rather than direction, both NANOG-to-partner and partner-to-NANOG results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, NANOG versus GLS2 in LSCC, with a Pearson correlation of 0.54.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NANOG→partner) and Y-score (partner→NANOG) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	GLS2 →	+0.398	+1.546	<.001	<.001	3	4
CCRCC	KISS1R →	-1.250	-0.680	.008	.001	3	3
PDAC	LONRF2 →	+0.794	+0.445	<.001	<.001	3	3
UCEC	RNA5SP241 →	+0.824	+0.419	.005	<.001	3	3
UCEC	VLDLR-AS1 →	+0.818	+0.547	<.001	.001	3	3
LSCC	RN7SL430P →	+0.790	+1.293	.001	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,311 associations by consensus.

NANOG vs GLS2 — LSCC

Explore this scatter interactively →