NALCN-AS1

Across TCGA pan-cancer cohorts, NALCN-AS1 RNA is linked to patient survival in 17 of 34 cancer types, making it the most broadly survival-associated NALCN-AS1 data layer.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher NALCN-AS1 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated NALCN-AS1 expression acts as an unfavorable survival marker, although some lineages such as READ and ESCA show a favorable association.

KIRC, BLCA, and KICH are the cancer types where NALCN-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	OS	Median	All	0.504	0.739	<.001	99	view →
BLCA	DFS	Quartile	III,IV	0.144	0.416	<.001	81	view →
KICH	DFS	Quartile	III,IV	0.085	0.891	.003	38	view →
UVM	DFS	Tertile	III,IV	0.137	0.811	.002	27	view →
HNSC	OS	Tertile	III,IV	0.181	0.555	.004	26	view →
READ	OS	Quartile	III,IV	0.920	0.302	.003	20	view →
ESCA	DFS	Tertile	III,IV	0.523	0.299	.026	16	view →
CHOL	DFS	Median	III,IV	0.127	0.647	.006	15	view →
OV	DFS	Tertile	IV	0.339	0.638	.006	12	view →
LIHC	DFS	Quartile	II,III,IV	0.320	0.594	.016	12	view →
MESO	OS	Median	All	0.304	0.454	.014	9	view →
SKCM	OS	Quartile	IV	1.000	0.172	.012	8	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 17 lineages.

NALCN-AS1–KIRC (OS)

Open the KIRC breakdown →