NALCN-AS1

Across TCGA pan-cancer cohorts, NALCN-AS1 RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of NALCN-AS1’s most consistent transcriptional readouts.

The strongest signal is observed in lung squamous cell carcinoma (LUSC), where NALCN-AS1 RNA is repressed in tumor relative to normal tissue. In most cancer types NALCN-AS1 is over-expressed in tumor, although a few such as LUSC and LUAD show the opposite, repressed pattern.

LUSC, LUAD, and HNSC are the cancer types where NALCN-AS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in NALCN-AS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUSC	All	II,III,IV	−0.533	<.001	6	view →
LUAD	All	All	−0.482	<.001	5	view →
HNSC	All	II,III,IV	+0.180	.012	5	view →
BLCA	Male	All	−0.728	.026	4	view →
CHOL	All	All	+0.236	<.001	3	view →
READ	All	III,IV	+0.115	.009	2	view →
PRAD	All	All	+0.074	<.001	2	view →
KIRC	Male	All	+0.047	.010	2	view →
LIHC	Male	III,IV	−0.046	.048	1	view →
KICH	Female	All	+0.045	.044	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

NALCN-AS1–LUSC

Open the LUSC breakdown →