NAGS

Across TCGA cell cohorts, NAGS mutation is significantly associated with the RNA expression of many other genes, with 3 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible NAGS-associated genes across cancer lineages are OR14K1, TSGA13, and CENPVL3. Each is linked with NAGS in more than 1 cancer types. Because this analysis shows association rather than direction, both NAGS-to-partner and partner-to-NAGS results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR14K1 grouped by NAGS-low versus NAGS-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NAGS→partner) and Y-score (partner→NAGS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	OR14K1 →	+0.058	+3.700	<.001	.009	3	1
LARGE_INTESTINE	TSGA13 →	+0.184	+2.994	.002	.006	3	1
LARGE_INTESTINE	CENPVL3 →	+0.249	+3.242	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

OR14K1 by NAGS expression — LARGE_INTESTINE

Explore this box plot interactively →