NAGLU

Across TCGA patient cohorts, NAGLU mutation is significantly associated with the RNA expression of many other genes, with 510 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NAGLU-associated genes across cancer lineages are TOMM22P1, RNU6-99P, and PPIAP69. Each is linked with NAGLU in more than 2 cancer types. Because this analysis shows association rather than direction, both NAGLU-to-partner and partner-to-NAGLU results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TOMM22P1 grouped by NAGLU-low versus NAGLU-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NAGLU→partner) and Y-score (partner→NAGLU) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	TOMM22P1 →	+0.465	+5.080	<.001	.008	3	3
LGG	RNU6-99P →	+0.248	+7.977	<.001	.007	3	2
BLCA	PPIAP69 →	+0.161	+4.588	<.001	.008	3	2
CESC	TRMT112P1 →	+0.099	+4.669	<.001	.007	3	2
LUSC	LINC02796 →	+0.123	+3.814	.008	.009	3	2
LUSC	RNU6-75P →	+0.594	+4.297	<.001	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 510 associations by consensus.

TOMM22P1 by NAGLU expression — COAD

Explore this box plot interactively →