NAGK

Across TCGA pan-cancer cohorts, NAGK mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated NAGK data layer compared with 26 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher NAGK mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated NAGK expression acts as an unfavorable survival marker, although some lineages such as HNSC and LSCC show a favorable association.

HNSC, LUAD, and COAD are the cancer types where NAGK mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	All	0.908	0.781	.015	11	view →
LUAD	OS	Median	III,IV	0.298	0.808	.013	11	view →
COAD	DFS	Median	III,IV	0.895	1.000	.039	6	view →
LSCC	DFS	Tertile	II,III,IV	1.000	0.399	.040	2	view →
GBM	OS	Tertile	All	0.323	0.576	.029	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

NAGK–HNSC (OS)

Open the HNSC breakdown →