NAGK

Across TCGA pan-cancer cohorts, NAGK RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of NAGK’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where NAGK RNA is more highly expressed in tumor relative to normal tissue. In most cancer types NAGK is over-expressed in tumor, although a few such as KICH and HNSC show the opposite, repressed pattern.

KIRC, KICH, and BRCA are the cancer types where NAGK tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in NAGK RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	IV	+0.799	<.001	12	view →
KICH	Female	II,III,IV	−1.130	<.001	7	view →
BRCA	All	III,IV	+0.627	<.001	6	view →
HNSC	All	II,III,IV	−0.532	<.001	6	view →
LIHC	Female	II,III,IV	+0.838	<.001	4	view →
LUSC	All	All	+0.347	<.001	4	view →
CHOL	Male	All	+1.755	<.001	3	view →
BLCA	All	IV	+0.742	.031	3	view →
PAAD	All	All	−0.710	.018	2	view →
PRAD	All	All	−0.185	.014	2	view →
STAD	Female	III,IV	+0.655	.049	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

NAGK–KIRC

Open the KIRC breakdown →