NAE1

Across TCGA patient cohorts, NAE1 RNA expression is significantly associated with the protein abundance of many other proteins, with 17,790 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible NAE1-associated proteins across cancer lineages are DHX38, USP10, and EDC4. Each is linked with NAE1 in more than 9 cancer types. Because this analysis shows association rather than direction, both NAE1-to-partner and partner-to-NAE1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, NAE1 versus DHX38 in HNSC, with a Pearson correlation of 0.29.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (NAE1→partner) and Y-score (partner→NAE1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	DHX38 →	+0.233	+0.493	.001	<.001	3	10
OV	USP10 →	+0.380	+0.659	<.001	<.001	3	8
BRCA	EDC4 →	+0.264	+0.616	<.001	<.001	3	8
GBM	CFDP1 →	+0.345	+0.349	<.001	<.001	3	7
GBM	CIAPIN1 →	+0.357	+0.599	<.001	<.001	3	7
LSCC	PUS7 →	+0.330	+0.644	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 17,790 associations by consensus.

NAE1 vs DHX38 — HNSC

Explore this scatter interactively →