NAE1

Across TCGA patient cohorts, NAE1 mutation is significantly associated with the RNA expression of many other genes, with 2,423 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NAE1-associated genes across cancer lineages are TMCC2-AS1, LINC01180, and HMGN2P11. Each is linked with NAE1 in more than 1 cancer types. Because this analysis shows association rather than direction, both NAE1-to-partner and partner-to-NAE1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TMCC2-AS1 grouped by NAE1-low versus NAE1-high in READ.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NAE1→partner) and Y-score (partner→NAE1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
READ	TMCC2-AS1 →	+0.131	+4.925	<.001	.004	3	2
READ	LINC01180 →	+0.042	+4.361	.001	.006	3	2
LUAD	HMGN2P11 →	+0.251	+3.615	<.001	.008	3	2
LUAD	MLLT10P2 →	+0.129	+5.924	<.001	<.001	3	2
LUAD	RFPL4AP3 →	+0.064	+4.584	.002	.005	3	2
LUAD	RNA5SP73 →	+0.508	+3.700	<.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,423 associations by consensus.

TMCC2-AS1 by NAE1 expression — READ

Explore this box plot interactively →