NADK

Across TCGA patient cohorts, NADK mutation is significantly associated with the total protein of many other genes, with 17 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NADK-associated genes across cancer lineages are STAT3_pY705, 14-3-3_beta, and ERK2. Each is linked with NADK in more than 1 cancer types. Because this analysis shows association rather than direction, both NADK-to-partner and partner-to-NADK results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, STAT3_pY705 grouped by NADK-low versus NADK-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NADK→partner) and Y-score (partner→NADK) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	STAT3_pY705 →	-0.227	-1.700	.041	.044	3	1
UCEC	14-3-3_beta →	-0.125	-1.847	.003	.049	3	1
UCEC	ERK2 →	+0.243	+1.700	.002	.044	3	1
UCEC	JNK2 →	+0.259	+2.834	.002	.034	3	1
UCEC	MEK1 →	+0.575	+4.000	<.001	<.001	3	1
UCEC	Mre11 →	-0.095	-1.700	.009	.044	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 17 associations by consensus.

STAT3_pY705 by NADK expression — UCEC

Explore this box plot interactively →