NADK

Across TCGA pan-cancer cohorts, NADK RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated NADK data layer compared with 6 for mutation status and 4 for mass-spec protein.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher NADK RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated NADK expression acts as an unfavorable survival marker, although some lineages such as MESO and UCS show a favorable association.

KIRC, LGG, and ACC are the cancer types where NADK RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	DFS	Median	III,IV	0.548	0.729	.002	58	view →
LGG	OS	Median	All	0.328	0.600	<.001	54	view →
ACC	DFS	Tertile	All	0.301	0.743	.001	35	view →
KICH	DFS	Quartile	II,III,IV	0.605	1.000	.006	27	view →
MESO	OS	Tertile	IV	0.897	0.458	.012	27	view →
UVM	DFS	Median	III,IV	0.467	0.854	.017	26	view →
UCS	OS	Median	IV	0.817	0.302	.002	24	view →
THCA	OS	Tertile	All	0.980	0.995	.015	24	view →
LUSC	DFS	Tertile	III,IV	0.232	0.862	.006	22	view →
CHOL	DFS	Median	All	0.728	0.122	.002	21	view →
SCLC	DFS	Quartile	II,III,IV	0.609	0.210	.010	18	view →
KIRP	DFS	Tertile	IV	0.043	0.762	.010	18	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

NADK–KIRC (DFS)

Open the KIRC breakdown →