NACC2

Across TCGA cell cohorts, NACC2 mutation is significantly associated with the RNA expression of many other genes, with 8 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible NACC2-associated genes across cancer lineages are POU3F4, MAGEB4, and STRA8. Each is linked with NACC2 in more than 1 cancer types. Because this analysis shows association rather than direction, both NACC2-to-partner and partner-to-NACC2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, POU3F4 grouped by NACC2-low versus NACC2-high in LIVER.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NACC2→partner) and Y-score (partner→NACC2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	POU3F4 →	+0.319	+3.977	<.001	.006	3	1
LARGE_INTESTINE	MAGEB4 →	+0.022	+4.415	<.001	.007	3	1
LARGE_INTESTINE	STRA8 →	+0.161	+4.415	<.001	.007	3	1
LARGE_INTESTINE	S100G →	+2.043	+4.273	<.001	.006	3	1
LARGE_INTESTINE	UTF1 →	+0.028	+5.217	<.001	<.001	3	1
LARGE_INTESTINE	ZNF804B →	+0.016	+4.415	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

POU3F4 by NACC2 expression — LIVER

Explore this box plot interactively →