NACAD

Across TCGA patient cohorts, NACAD protein abundance is significantly associated with the RNA expression of many other genes, with 4,539 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible NACAD-associated genes across cancer lineages are SYT11, NRXN2, and ENOX1. Each is linked with NACAD in more than 3 cancer types. Because this analysis shows association rather than direction, both NACAD-to-partner and partner-to-NACAD results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, NACAD versus SYT11 in UCEC, with a Pearson correlation of 0.38.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NACAD→partner) and Y-score (partner→NACAD) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SYT11 →	+0.854	+0.592	.004	.006	3	4
GBM	NRXN2 →	+1.255	+0.339	.001	.007	3	3
LSCC	ENOX1 →	+0.617	+0.568	<.001	<.001	3	3
PDAC	MYH2 →	+0.423	+0.441	.003	.003	3	3
LUAD	PXDN →	+1.114	+0.697	<.001	<.001	3	3
UCEC	C1QTNF2 →	+0.788	+0.758	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,539 associations by consensus.

NACAD vs SYT11 — UCEC

Explore this scatter interactively →