NACAD

Across TCGA pan-cancer cohorts, NACAD RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of NACAD’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where NACAD RNA is repressed in tumor relative to normal tissue. In most cancer types NACAD is over-expressed in tumor, although a few such as COAD and KIRC show the opposite, repressed pattern.

COAD, KIRC, and UCEC are the cancer types where NACAD tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in NACAD RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Male	All	−1.110	<.001	9	view →
KIRC	Male	II,III,IV	−0.913	<.001	9	view →
UCEC	All	III,IV	−2.112	<.001	6	view →
BRCA	Female	All	−1.156	<.001	6	view →
HNSC	All	All	+0.483	.002	6	view →
STAD	All	All	−1.134	.001	5	view →
BLCA	Female	III,IV	−0.962	.010	4	view →
LUSC	All	II,III,IV	−0.506	<.001	4	view →
LUAD	All	All	−0.483	<.001	4	view →
READ	All	All	−1.466	<.001	2	view →
PRAD	All	All	−0.899	<.001	2	view →
CHOL	All	All	+0.588	<.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

NACAD–COAD

Open the COAD breakdown →