NACAD

Across TCGA patient cohorts, NACAD mutation is significantly associated with the total protein of many other genes, with 25 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NACAD-associated genes across cancer lineages are ATM, 4E-BP1, and Lck. Each is linked with NACAD in more than 2 cancer types. Because this analysis shows association rather than direction, both NACAD-to-partner and partner-to-NACAD results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by NACAD-low versus NACAD-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NACAD→partner) and Y-score (partner→NACAD) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.440	-1.736	.005	.007	3	3
UCEC	4E-BP1 →	+0.319	+2.070	<.001	.001	3	3
UCEC	Lck →	+0.205	+1.700	.003	.042	3	2
UCEC	PDCD4 →	-0.387	-1.874	.017	.049	3	2
UCEC	EGFR_pY1068 →	-0.230	-2.502	.008	.001	3	1
UCEC	ERK2 →	+0.198	+3.087	.002	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 25 associations by consensus.

ATM by NACAD expression — UCEC

Explore this box plot interactively →