NACAD

Across TCGA cell cohorts, NACAD RNA expression is significantly associated with the go_rna of many other GO terms, with 3,212 significant associations in total. CNS shows the largest number of these associations.

The most reproducible NACAD-associated GO terms across cancer lineages are Negative regulation of syncytium formation by plasma membrane fusion, Negative regulation of myoblast fusion, and Regulation of proteasomal protein catabolic process. Each is linked with NACAD in more than 16 cancer types. Because this analysis shows association rather than direction, both NACAD-to-partner and partner-to-NACAD results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of syncytium formation by plasma membrane fusion grouped by NACAD-low versus NACAD-high in OVARY.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (NACAD→partner) and Y-score (partner→NACAD) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	Negative regulation of syncytium formation by plasma membrane fusion →	+0.115	+1.009	<.001	.005	3	17
OVARY	Negative regulation of myoblast fusion →	+0.111	+0.881	<.001	.002	3	15
STOMACH	Regulation of proteasomal protein catabolic process →	+0.074	+0.998	<.001	.006	3	14
LUNG_SCLC	Purine ribonucleoside triphosphate metabolic process →	+0.076	+1.614	.001	.001	3	13
LUNG_SCLC	RNA splicing, via transesterification reactions →	+0.055	+1.916	.005	.001	3	12
OVARY	Regulation of syncytium formation by plasma membrane fusion →	+0.100	+0.813	<.001	.006	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,212 associations by consensus.

Negative regulation of syncytium formation by plasma membrane fusion by NACAD expression — OVARY

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