NACAD

Across TCGA cell cohorts, NACAD mutation is significantly associated with the RNA expression of many other genes, with 210 significant associations in total. CNS shows the largest number of these associations.

The most reproducible NACAD-associated genes across cancer lineages are RS1, ASZ1, and EVX1. Each is linked with NACAD in more than 1 cancer types. Because this analysis shows association rather than direction, both NACAD-to-partner and partner-to-NACAD results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RS1 grouped by NACAD-low versus NACAD-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NACAD→partner) and Y-score (partner→NACAD) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	RS1 →	+0.133	+3.564	<.001	.003	3	2
BLOOD_Leukemia	ASZ1 →	+0.087	+3.889	.002	<.001	3	2
CNS	EVX1 →	+0.080	+3.911	.001	<.001	3	1
CNS	PRMT8 →	+0.231	+2.330	.004	.007	3	1
CNS	FBXO5 →	-0.712	-3.321	<.001	.007	3	1
CNS	CENPL →	-0.567	-3.271	.004	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 210 associations by consensus.

RS1 by NACAD expression — BLOOD_Leukemia

Explore this box plot interactively →