Across TCGA patient cohorts, NACA mutation is significantly associated with the RNA expression of many other genes, with 6,451 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NACA-associated genes across cancer lineages are MIR4650-2, WNT5B, and RNA5SP420. Each is linked with NACA in more than 3 cancer types. Because this analysis shows association rather than direction, both NACA-to-partner and partner-to-NACA results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NACA→partner) and Y-score (partner→NACA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	MIR4650-2 →	+0.475	+5.841	.003	.003	3	4
UCEC	WNT5B →	-0.803	-2.129	.001	<.001	3	4
UCEC	RNA5SP420 →	+0.480	+1.797	<.001	<.001	3	4
UCEC	UHRF1 →	+0.967	+2.470	<.001	<.001	3	3
UCEC	SCNN1B →	-1.227	-1.536	<.001	.002	3	3
UCEC	PRC1 →	+0.720	+2.192	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,451 associations by consensus.

Exploration

NACA survival (RNA) · tumor vs normal (RNA) · all NACA data types