Across TCGA cell cohorts, NACA mutation is significantly associated with the RNA expression of many other genes, with 1,134 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible NACA-associated genes across cancer lineages are CRLF3, PHLPP2, and KDM3B. Each is linked with NACA in more than 2 cancer types. Because this analysis shows association rather than direction, both NACA-to-partner and partner-to-NACA results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NACA→partner) and Y-score (partner→NACA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	CRLF3 →	+0.590	+3.263	.001	.005	3	3
SKIN	PHLPP2 →	+0.463	+3.234	.004	.004	3	3
LARGE_INTESTINE	KDM3B →	+0.460	+3.237	.002	.003	3	3
LARGE_INTESTINE	FEM1A →	+0.644	+2.502	<.001	.005	3	3
LARGE_INTESTINE	MAML1 →	+0.527	+3.082	.003	.007	3	3
BLOOD_Leukemia	ZNF821 →	+0.621	+2.674	.002	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,134 associations by consensus.

Exploration

NACA survival (RNA) · tumor vs normal (RNA) · all NACA data types