NAALADL2

Across TCGA patient cohorts, NAALADL2 mutation is significantly associated with the total protein of many other genes, with 42 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NAALADL2-associated genes across cancer lineages are 4E-BP1, Cyclin-B1, and eEF2. Each is linked with NAALADL2 in more than 2 cancer types. Because this analysis shows association rather than direction, both NAALADL2-to-partner and partner-to-NAALADL2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 4E-BP1 grouped by NAALADL2-low versus NAALADL2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NAALADL2→partner) and Y-score (partner→NAALADL2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	4E-BP1 →	+0.262	+2.222	.002	.009	3	3
UCEC	Cyclin-B1 →	+0.744	+2.321	<.001	<.001	3	3
SKCM	eEF2 →	+0.298	+1.807	.027	.026	3	2
UCEC	ACC1 →	+0.265	+1.459	.024	.012	3	2
UCEC	14-3-3_beta →	-0.110	-1.986	<.001	<.001	3	2
UCEC	FoxM1 →	+0.204	+1.716	.015	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 42 associations by consensus.

4E-BP1 by NAALADL2 expression — UCEC

Explore this box plot interactively →