NAALADL1

Across TCGA pan-cancer cohorts, NAALADL1 Mutation is linked to patient survival in 4 of 34 cancer types, making it a survival-associated NAALADL1 data layer compared with 23 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher NAALADL1 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated NAALADL1 expression acts as an unfavorable survival marker.

HNSC, KIRC, and LUAD are the cancer types where NAALADL1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	All	0.136	0.687	.001	42	view →
KIRC	DFS	Median	All	0.180	0.796	.001	30	view →
LUAD	OS	Median	All	0.237	0.788	.008	9	view →
BLCA	OS	Median	IV	0.251	0.606	.021	6	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

NAALADL1–HNSC (OS)

Open the HNSC breakdown →